张成岗，军事医学科学院放射与辐射医学研究所研究员，神经生物学研究室主任，全
军基因组学与蛋白质组学重点实验室副主任。36 岁，祖籍陕西白水，1992 年于复旦
大学获理学学士学位，1995 年于第四军医大学获医学硕士学位，1998 年于第三军医
大学获医学博士学位，2000 年于军事医学科学院放射与辐射医学研究所博士后出站。
曾经从事过神经肽NPY 及CGRP、新生长因子nov 基因的功能以及人胎肝来源新基
因的规模化发掘的研究工作。近年来主要从事分子神经生物学与生物信息学的研究工
作，研究兴趣在于脑损伤及脑保护、神经可塑性、生物信息学等多方面。先后主持或
作为主要参加者参与了20 项基金资助项目的科研工作，包括国家“973”计划项目1 项、
国家/军队“863”项目4 项、国家自然科学基金项目7 项、北京市科研基金4 项(包括北
- 6 -
京市自然科学基金重点项目1 项和北京市科技新星计划A 类1 项)、本院科研创新启
动基金课题3 项等。出版专著一部《生物信息学方法与实践》 (目前已印刷11500 册)。
曾在Brain Res、Mol Brain Res、Glia、Faseb J、Genome Res、JBC、BBRC、Genomics、
Radiat Res 等国外期刊发表论著近30 篇，影响因子合计90 分以上；在国内核心期刊
发表90 余篇。有关文献被SCI 期刊引用150 次以上。先后获得国家自然科学二等奖
1 项、北京市科技进步一等奖1 项、军队科技进步二等奖3 项，申请中国发明专利6
项。现为中国神经科学学会分子神经生物学专业第三届委员会委员、中华医学会高原
医学分会第五届委员会委员、中国中西医结合学会灾害医学专业第一届委员会委员、
全国第二届遗传学名词审定委员会委员、《生物信息学》杂志编委及Stroke、Proteomics、
BBA-Proteins 《Proteomics、Genomics, Proteomics & Bioinformatics》、《中国科学(C
缉)》、《生物化学与生物物理进展》、《生物物理学报》、《生理学报》、《遗传学报》、《遗
传》、《中国生物化学与分子生物学报》等刊物特邀审稿人。发表论著如下：
1. 张成岗, 贺福初. 生物信息学方法与实践. 北京: 科学出版社, 2002, 共290 页 (至2005
年8 月已印刷11500 册)
2. 高艳，秦树桐，张成岗(通讯作者). 高功率微波照射对原代培养神经细胞活性的影响. 中
华放射医学与防护, 2006(印刷中)
3. 毛逸清，赵东升，李稚锋，杭兴宜，骆志刚，张成岗(通讯作者). 大规模EST 序列聚类
的并行算法研究进展. 军事医学科学院院刊, 2006(印刷中)
4. 李佩尧, 张成岗(通讯作者). 细胞缺氧感受器：缺氧诱导因子-1 脯氨酰羟化酶研究进展.
生理科学进展, 2006(印刷中)
5. 尚爱加, 周定标, 孟祥辉, 王利红, 张成岗(通讯作者). 脑缺血再灌注损伤后脑红蛋白在
大脑皮层和海马区的表达变化. 解放军医学杂志, 2006(印刷中)
6. 刘铖，高艳，秦树桐，文圣梅，王利红，张成岗(通讯作者). 脑红蛋白(NGB)重组腺病毒
表达载体的构建与鉴定. 军事医学科学院院刊, 2006(印刷中)
7. 李谋，王春丽，刘小林，张成岗(通讯作者). Na+-K+-ATPase 1β2 亚基酵母双杂交载体的
构建与表达鉴定. 西北农林科技大学学报, 2006(印刷中)
8. 李佩尧，张成岗(通讯作者). 星形胶质细胞分泌血小板反应蛋白(TSP)促进神经突触形成.
军事医学科学院院刊, 2006(印刷中)
9. Shang A, Zhou D, Wang L, Gao Y, Fan M, Wang X, Zhou R, Zhang C(Corresponding
author). Increased neuroglobin levels in the cerebral cortex and serum after
ischemia-reperfusion insults. Brain Res. 2006, 1078(1):219-226
10. Keke Yu, Shutong Qin, Siying Wang, Renping Zhou, Chenggang Zhang(Corresponding
author). A preliminary study on the receptor for axon guidance factor Netrin-4. Neuroscience
Bulletin. 2005, 21(3):175-181
11. Chenggang Zhang(Corresponding author), Fanwei Meng, Chunli Wang, Huiyun Guo,
Ming Fan,Shaojun Liu, Renping Zhou, Fuchu He. Identification of a novel alternative
splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. Mol
Brain Res, 2004, 130(1-2):68-80 (*为该期封面文章)
12. Chen TF, Zhang YL, Xu WL, Li ZQ, Hou B, Wang CL, Fan M, Qian LJ, Zhou RP, Zhang
CG(Corresponding author). Prokaryotic expression, polyclonal antibody preparation, and
sub-cellular localization analysis of Na+, K+-ATPase beta2 subunit. Protein Expr Purif. 2004;
37(1):47-52.
13. Qi Zhou, Hong Zhang, Meiying Geng, Chenggang Zhang (Corresponding author). A
real-time and dynamic biological information retrieval and analysis system (BIRAS).
Genomics, Proteomics and Bioinformatics, 2003, 1(1):74-77.
14. Chenggang Zhang (Corresponding author), Chunli Wang, Meiyu Deng, Lin Li, Hangyan
Wang, Ming Fan, Wenlin Xu, Fanwei Meng, Lingjia Qian, Fuchu He. Full-length cDNA
cloning of human neuroglobin and tissue expression of rat neuroglobin. Biochem Biophys Res
Commun. 2002, 290 (5):1411-1419.
15. Chenggang Zhang, Yongtao Yu, Shaowen Zhang, Mengmin Liu, Guichun Xing, Handong
Wei, Jianjin Bi, Xiaoqin Liu, Gangqiao Zhou, Chunna Dong, Zhiyuan Hu, Yong Zhang, Ling
Luo, Chutse Wu, Shifu Zhao, Fuchu He. Characterization, chromosomal assignment, and
tissue expression of a novel human gene belonging to the ARF GAP family. Genomics. 2000,
63 (3): 400-408
16. Chenggang Zhang (Corresponding author), Wenqin Cai, Yu Li, Weiquan Huang, Huici Su.
Quantitative analysis of calcitonin gene-related peptide and neuropeptide Y-immunoreactive
nerve fibers in mesenteric blood vessels of irradiated rats with Cobalt-60 gamma rays. Radiat
Res. 1998, 149 (1):19-26
17. Chen XQ, Qin LY, Zhang CG, Yang LT, Gao Z, Liu S, Lau LT, Fung YW, Greenberg DA,
Yu AC. Presence of neuroglobin in cultured astrocytes. Glia. 2005;50(2):182-186.
18. Qiao YH, Liu JL, Zhang CG, Xu XH, Zeng YJ. SVM classification of human intergenic and
gene sequences. Mathematical Biosciences, 2005, 195:168-178
19. Qiao YH, Liu JL, Zhang CG, Zeng YJ. Finding keywords for intergenic and gene regions for
human genome. Nucleosides, Nucleotides, and Nucleic Acids, 24(3):191-198, 2005
20. Wang Z, Wei H, Yu Y, Sun J, Yang Y, Xing G, Wu S, Zhou Y, Zhu Y, Zhang C Zhou T,
Zhao X, Sun Q, He F. Characterization of Ceap-11 and Ceap-16, two novel
splicing-variant-proteins, associated with centrosome, microtubule aggregation and cell
proliferation. J Mol Biol. 2004, 343(1):71-82.
21. Chengrong Lu, Yong Li, Yanlin Zhao, Guichun Xing, Fei Tang, Qingming Wang, Yuhui Sun,
Handong Wei, Xiaoming Yang, Chutse Wu, Jianguo Chen, Kunliang Guan, Chenggang
Zhang, Huipeng Chen, Fuchu He. Intracrine hepatopoietin potentiates AP-1 activity through
JAB1 independent of MAPK pathway. FASEB J. 2002, 16 (1):90-2.
22. Xianghu Qu, Yun Zhai, Handong Wei, Chenggang Zhang, Guichun Xing, Yongtao Yu,
Fuchu He. Characterization and expression of three novel differentiation-related genes belong
to the human NDRG gene family. Mol Cell Biochem. 2002, 229:35-44

23. Yongtao Yu, Chenggang Zhang, Gangqiao Zhou, Songfeng Wu, Xianghu Qu, Handong Wei,
Guichun Xing, Chunna Dong, Yun Zhai, Jinghong Wan, Shuguang Ouyang, Li Li, Shaowen
Zhang, Kaixin Zhou, Yinan Zhang, Chutse Wu, Fuchu He. Gene expression profiling in
human fetal liver and identification of tissue- and developmental-stage-specific genes through
compiled expression profiles and efficient cloning of full-length cDNAs. Genome Res. 2001,
11 (8):1392-1403
24. Xiaoqin Liu, Chenggang Zhang, Guichun Xing, Qingtang Chen, Fuchu He. Functional
characterization of novel human ARFGAP3. FEBS Lett. 2001, 490 (1-2):79-83
25. Xianghu Qu, Chenggang Zhang, Yun Zhai, Guichun Xing, Handong Wei, Yongtao Yu,
Songfeng Wu, Fuchu He. Characterization and tissue expression of a novel human gene npdc1.
Gene. 2001, 264 (1):37-44
26. Bingyin Su, Weiqin Cai, Chenggang Zhang, Martinez V., Lombet A., Perbal B. The
expression of ccn3 (nov) RNA and protein in the rat central nervous system is
developmentally regulated. J Clin Pathol: Mol Pathol. 2001, 54 (3):184-191
27. Yong Li, Ming Li, Guichun Xing, Zhiyuan Hu, Qingming Wang, Chunna Dong, Handong
Wei, Guocai Fan, Jizhong Chen, Xiaoming Yang, Shifu Zhao, Huipeng Chen, Kunliang Guan,
Chutse Wu, Chenggang Zhang, Fuchu He. Stimulation of the mitogen-activated protein
kinase cascade and tyrosine phosphorylation of the epidermal growth factor receptor by
hepatopoietin. J Biol Chem. 2000, 275 (48):37443-7
28. Shaowen Zhang, Chenggang Zhang, Yongtao Yu, Bingzhi Mao, Fuchu He. DFT study on
structures and vibrational frequencies of (CS2)−2 . Chemical Physics Letters. 304:265-270,1999
29. Huici Su, Chenggang Zhang, Gerhard W. Hacker. CGRP-immunoreactive nerve fibers in the
superior mesenteric arteries and veins of rat. Cell Vision. 3 (1):35-39, 1996.
30. Huici Su, Chenggang Zhang, Jiang Gu. Comparison of NPY-immunoreactive nerves in the
superior mesenteric artery and vein in rat. Cell Vision. 2 (5):382-386, 1995.
31. Bingyin Su, Wenqin Cai, Chenggang Zhang, Huici Su, Perbal B. A developmental study of
novH gene expression in human central nervous system. C. R. Acad. Sci. Paris, Sciences de la
vie/Life Sciences. 1998, 321:883-892
32. Bingyin Su, Wenqin Cai, Chenggang Zhang, Perbal B. Developmental study on the
immunocytochemical localization of NOV protein-containing neurons in the rat brain.
Chinese Sci Bull. 1999, 44 (15):1397-1401
33. Ruian Wang, Wenqin Cai, Chenggang Zhang, Stridsberg M., Huici Su. Mutual relationships
between contents of chromagranin A, cholecystokinin octapeptide and serotonin in individual
EC cells. Chinese Sci Bull. 1995, 40 (5): 417-421
34. Ge Wang, Xiaoming Yang, Yong Zhang, Qingming Wang, Huipeng Chen, Handong Wei,
Guichun Xing, Ling Xie, Zhiyuan Hu, Chenggang Zhang, Dianchun Fang, Chutse Wu,
Fuchu He. Identification and characterization of receptor for mammalian hepatopoietin that is
homologous to yeast ERV1. J Biol Chem. 1999, 274 (17):11469-72
35. Changsheng Chen, Yongyong Xu, Chenggang Zhang. Linearly optimum seeking K-value in　the fitting of exponential and geometric curves. J Med Coll PLA. 1996, 11 (4):314-316